Trials often track cholesterol, tumor shrinkage or blood sugar instead of death, fractures or survival — the stand-in usually works, but history records the exceptions.
Relative risk makes small dangers look enormous and big benefits look magical; converting to absolute numbers takes one minute and changes every conclusion.
A cleared device reached the market by demonstrating similarity to a decades-old predicate; an approved drug faced clinical trials — knowing which word your product carries changes its evidentiary weight.
Meta-analyses sit at the top of the evidence pyramid, but pooling inherits every flaw of the studies it combines — heterogeneity, publication bias and garbage in.
Industry funding skews research results in measurable, documented ways — and the disclosures at the bottom of a paper tell you which way to lean your skepticism.